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March 29, 2005

New Treatment May curb Cat Allergies



New Treatment May curb Cat Allergies
According to a report in the journal Nature Medicine a hybrid molecule designed to block cat allergies has successfully prevented allergic reactions in laboratory mice and human cells, promising new treatments for a range of human allergies. The treatment, developed by researchers at the University of California, Los Angeles, comprises a molecule containing a feline and human protein. The treatment stops the release of histamine, the chemical that brings on allergy symptoms such as sneezing, wheezing, itching and watery eyes. Immune cells in people allergic to cats produce histamine in response to proteins found in cat saliva and dander reports betterhumans.com.

Gamma feline domesticus (GFD), the hybrid molecule was first tested in blood donated by people allergic to cats. In two different types of engineered allergic mice, GFD also blocked the allergic reaction.

"We measured more than 90% less histamine in the cultures with GFD," says researcher Andrew Saxon, MD, of UCLA. "Those results suggested that GFD successfully prevented the immune cells from reacting to cat allergen. The next step was to test GFD in mice that we had made allergic to the allergenic protein found in cat saliva and dander."

Saxon says the molecule could prevent allergic reactions long after injections cease, but further research and clinical testing are required before it can be used in humans.



 






 

 

 

 






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