The thriller tells the story of Aubrey Fleming, a woman who is abducted and tortured by a sadistic serial killer. When she finally manages to escape and regain consciousness she insists she is a stripper called Dakota Moss and the real Aubrey Fleming is still in danger.
Lindsay - who did not turn up to the ceremony - received two Worst Actress awards for playing both Aubrey and Dakota in the film, as well as winning the Worst On Screen Couple prize for a sequence where both women appear on screen together.
The film, which cost £6 million to make and only made £3.8 million in the US, also scooped the Worst Remake or Rip-off, Worst Director, Worst Screenplay and Worst Excuse for a Horror Movie award.
The film broke the previous record of seven awards - jointly held by 'Showgirls' and 'Battlefield Earth'.
One critic said about 'I Know Who Killed Me': "It was a mystery at the beginning and it was still a mystery at the end. It was as if a script had been put in a blender and this is what came out."
Meanwhile, Eddie Murphy was awarded the Worst Actor, Worst Supporting Actor and Worst Supporting Actress prizes for playing three characters in the comedy 'Norbit'.
Eddie and Lindsay were also voted for giving the poorest acting performances of 2007, in a poll of conducted by AOL Moviefone earlier this year.