Immediately following Spears’ opening performance, Silverman said. “Was that incredible?" she asked the crowd. "She is amazing. I mean, she is 25 years old and she’s already accomplished everything she’s going to accomplish in her life.�?

She continued: “It’s weird to think that just a few years ago on this very show, she was this, like, sweet innocent little girl in slutty clothes writhing around with a python. That’s not nice…calling Madonna a python.�?

Even Spears’ sons, Jayden and Sean, were slammed.

“Have you seen Britney’s kids? Oh my god, they are the most adorable mistakes you will ever see!�? Silverman trilled. “They are as cute as the hairless vagina they came out of.�?